I don't know how anyone can survive with only one email account anymore. With all of the spam I get, as well as emails from stores I like or Meet-Up groups I'm a part of, I could never keep it all straight with just one inbox (I already feel overwhelmed as it is!). So, I try to keep things organized with two personal email accounts. One is for family and friends, as well as receipts for any shopping I do (stores, plane tickets, etc.). I must say, although I disliked Gmail's new format of multiple tabs for your inbox [Primary, Social, and Promotions], it has certainly grown on me. Now, it will separate emails from my loved ones, from Twitter, and from my Living Social/Groupon emails. My second email address is for anything relating to Meet-Up, Belief Net, or online dating (well, it used to be for that until I gave OkCupid up...). These are emails that I eventually will get to, but I just don't need to look at them RIGHT now; they can wait.
And of course work emails are separate by nature. Imagine mixing personal AND professional emails with one another! That's like dating someone at work: it's messy.
How do you keep your inbox(es) tidy?